ProxySettingsPerUser resets to 0 on restart Windows 10

I've had an issue with the Win 10 settings menu recently, that it would not allow me to change proxy settings. Every time I set it to Automatically detect settings it would just change it back to Use setup script and my loopback IP as a script address. This caused me issues with various browsers, but changing the ProxySettingsPerUser key to 1 from 0 in Computer\HKEY_LOCAL_MACHINE\SOFTWARE\Policies\Microsoft\Windows\CurrentVersion\Internet Settings seemed to do the trick. Unfortunately this key seems to be reset to 0 every time I restart my PC, so I have to change it back every time.

Before I try something like removing write permissions from SYSTEM (which I saw recommended on different threads), I'd like to know if there is a better way of going about this, maybe running a .reg script at startup, or changing some other setting.

Any help is appreciated.

Forgot to clarify, I've checked for malware already using Malwarebytes.

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In this instance I’d use something like Process Monitor to see what is overwriting the setting. On my machine (W10 Build 19042) whenever I made the change manually using the Windows 10 settings, it was made to HKCU\SOFTWARE\Microsoft\Windows\CurrentVersion\Internet Settings\AutoConfigURL by the WinHTTP Web Proxy Auto-Discovery Service. Might be worth monitoring that reg path yourself.

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